Spike rate (Hz) Current (nA) 10 8 6 4 2 0 4.0 3.0 2.0 1.0 0.0 -1.0 -2.0

Figure 8.4i Tonic Firing. A cell with regular spontaneous activity was stimulated with 4 s of hyperpolarizing or depolarizing current. The top inset shows activity without stimulation; the lower inset shows activity with +2 nA of current. Note the period of reduced activity after the stimulus in this inset.

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