-80 -60 -40 -20 0 20 40 60 5 4 3 2 1 0 Membrane potential (mV) Time (s) 16 ms 27 ms 41 ms 52 ms 63 ms

Figure 8.2i Broadening and Accommodation. A Ca2+ cell with spontaneous activity was stimulated with depolarizing current. Each spke is wider than the previous one (spike broadening) due to increasing inactivation of the voltage-activated channels that carry the repolarizing K+ current. The interval between spikes increases (accommodation) due to a slowly developing outward K+ current that counters the depolarizing stimulus. This current also makes the membrane potential hyperpolarize slightly at the end of the stimulus.

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